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IRRITABLE BOWEL SYNDROME (IBS)

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What is IBS?

Irritable bowel syndrome (IBS) is a chronic and debilitating gastrointestinal disorder characterized by abdominal pain and a change in bowel habits (constipation and/or diarrhea)1,2.


IBS is the most common reason to seek help from a gastroenterologist (a specialist in digestive disorders).

IBS significantly reduces quality of life and is linked to major work productivity losses and increased healthcare costs due to co-existing conditions.

4-9%
(320-720 million) people globally are affected1,2
20-30
year olds are the most affected1,2
2x
as many women as men are diagnosed1,2
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Learn More Details about IBS

When is diet a good option for IBS, and when not?

Before making any diet changes, it is first essential to know if diet changes make sense:3

Making diet changes might help if
Food triggers symptoms
You do not have a history of an eating disorder, nor do you experience anxiety associated with food or eating
You have an interest in dietary treatment and have the resources to follow it
Consider non-dietary alternatives if
You have already extensively restricted your diet without symptom improvement
You are at risk of malnutrition
You suffer from an uncontrolled psychiatric disorder
You find that stress is the primary factor that triggers symptoms
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate.
People living with IBS run a higher risk of disordered eating due to a lack of interest in eating, avoidance of sensory characteristics of food, or fear of adverse eating consequences.4,5 

In particular, those with severe food restriction tend to have more severe symptoms, reduced quality of life, and reduced intake of nutrients.6 

Also, 41-52% of patients with eating disorders have IBS.7

Food could activate a variety of different mechanisms that are important in the onset and development of IBS. Sometimes the food ingredients themselves are the primary drivers of symptoms, but negative expectations alone can also trigger real symptoms, as seen with non-celiac gluten/wheat sensitivity.8 

The goal is to follow the most liberal and nutritious diet that helps maintain symptom control.

What are the symptoms of IBS?

Experiencing abdominal pain with a change in bowel habits is the key symptom of IBS. Depending on stool consistency, IBS is grouped into subtypes, including:13

  • IBS with diarrhea
  • IBS with constipation
  • IBS with mixed bowel patterns
Figure 2. IBS subtypes based on Bristol stool forms.14

Other common symptoms of IBS include:

  • bloating (a sensation of fullness in the belly)
  • excess gas
  • urgency (the need to rush to have a bowel movement)
  • mucus in the stool
  • the feeling of incomplete emptying after a bowel movement
After an episode of acute gastroenteritis (such as the result of food poisoning), postinfectious IBS may be diagnosed in people who previously did not have IBS. It occurs more frequently in women, in those exposed to antibiotics, and in patients who have a history of anxiety or depression.15

COVID-19 pandemic was also linked to a surge in IBS, with rates increasing from 6% to 11% among U.S. adults.16

IBS can be confidently diagnosed by a careful review of symptoms, a physical examination, and minimal diagnostic testing.

A reliable IBS diagnosis can be made by your gastroenterologist when:

  1. Ruling out alarm features or red flags:17
    • Onset of symptoms after age 50
    • Blood in the stool
    • Iron-deficiency anemia
    • Nocturnal (while sleeping) diarrhea
    • Weight loss
    • A family history of organic gastrointestinal disease: colorectal cancer, IBD, celiac disease

Patients with alarm features should be referred for further investigation before concluding they are suffering with IBS.

  1. The Rome IV Criteria for IBS are fulfilled for the last three months with symptom onset at least six months prior to diagnosis. You will have abdominal pain at least one day per week, along with at least two of the following18:
    • Related to defecation
    • Onset associated with a change in the frequency of stool
    • Onset associated with a change in the form (appearance) of stool
What are the causes of IBS?

While genetic predisposition can increase the likelihood that IBS will occur, additional inciting factors need to be present to develop IBS:

  • Childhood digestive troubles
  • History of previous physical, emotional, or sexual abuse
  • Parental modeling
  • Stress
  • Poor coping skills
  • Anxiety
  • Somatization
  • Depression
  • Infectious illnesses

IBS does not have a single cause and is considered a disorder of disturbed gut-brain interactions with different mechanisms involved:

  • Food sensitivities
  • Altered gut microbiota and metabolites
  • Increased intestinal permeability
  • Immune activation 
  • Visceral hypersensitivity (increased sensitivity of the internal organs to normal bodily sensations)
  • Psychological factors (stress, anxiety, and depression)
  • Abnormal gastrointestinal motility

Figure 3. Potential causes involved in the onset and development of IBS19.

A new theory suggests that a localized food allergy in the gut causes IBS pain. It turns out that a gut infection or stress can activate immune cells in the gut that mistakenly perceive food protein fragments (antigens) as enemies. After the  infection or stress disappears, the ingestion of food antigens again could explain the pain and cramping that often accompany a meal.20 

IBS isn't a single disease; it's a collection of distinct conditions for which we currently lack a definitive diagnostic test to categorize patients into true disease groups.

It’s important to discuss with the gastroenterologist if it makes sense to check for the following organic diseases, in case they are the root cause of the symptoms:21

  • Colorectal cancer
  • IBD (Crohn’s disease, ulcerative colitis, and microscopic colitis)
  • Gastrointestinal parasitic infections
  • Small intestinal bacterial overgrowth
  • Celiac disease
  • Bile acid diarrhea
  • Sucrase-isomaltase deficiency
  • Exocrine pancreatic insufficiency
  • Dyssynergic defecation

Since IBS can mimic many other medical issues, it is imperative that you do not self-diagnose with IBS and ask your physician to make a reliable diagnosis based on your symptoms and previous history.

Key components of integrated care for patients with IBS

Most diets for IBS rely on restricting well-known IBS triggers and only target gut symptoms. However, poor mental health is common in IBS and a higher psychological burden is associated with more visits to the gastroenterologist, more use of drugs for IBS, lower quality of life, and greater GI-specific anxiety.9

The management of IBS is not one-size-fits-all and involves multiple healthcare professionals and factors:10

  • Dietary therapies, including supplements, foods and drinks, and whole diets
  • Medical management
  • Behavioral management (e.g., gut-directed hypnotherapy)

Figure 1. The management of IBS is integrative and involves multiple evidence-based IBS treatments.10

When is diet a good option for IBS, and when not?

Before making any diet changes, it is first essential to know if diet changes make sense:3

Making diet changes might help if
Food triggers symptoms
You do not have a history of an eating disorder, nor do you experience anxiety associated with food or eating
You have an interest in dietary treatment and have the resources to follow it
Consider non-dietary alternatives if
You have already extensively restricted your diet without symptom improvement
You are at risk of malnutrition
You suffer from an uncontrolled psychiatric disorder
You find that stress is the primary factor that triggers symptoms
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate.
People living with IBS run a higher risk of disordered eating due to a lack of interest in eating, avoidance of sensory characteristics of food, or fear of adverse eating consequences.4,5 

In particular, those with severe food restriction tend to have more severe symptoms, reduced quality of life, and reduced intake of nutrients.6 

Also, 41-52% of patients with eating disorders have IBS.7

Food could activate a variety of different mechanisms that are important in the onset and development of IBS. Sometimes the food ingredients themselves are the primary drivers of symptoms, but negative expectations alone can also trigger real symptoms, as seen with non-celiac gluten/wheat sensitivity.8 

The goal is to follow the most liberal and nutritious diet that helps maintain symptom control.

What are the symptoms of IBS?

Experiencing abdominal pain with a change in bowel habits is the key symptom of IBS. Depending on stool consistency, IBS is grouped into subtypes, including:13

  • IBS with diarrhea
  • IBS with constipation
  • IBS with mixed bowel patterns
Figure 2. IBS subtypes based on Bristol stool forms.14

Other common symptoms of IBS include:

  • bloating (a sensation of fullness in the belly)
  • excess gas
  • urgency (the need to rush to have a bowel movement)
  • mucus in the stool
  • the feeling of incomplete emptying after a bowel movement
After an episode of acute gastroenteritis (such as the result of food poisoning), postinfectious IBS may be diagnosed in people who previously did not have IBS. It occurs more frequently in women, in those exposed to antibiotics, and in patients who have a history of anxiety or depression.15

COVID-19 pandemic was also linked to a surge in IBS, with rates increasing from 6% to 11% among U.S. adults.16

IBS can be confidently diagnosed by a careful review of symptoms, a physical examination, and minimal diagnostic testing.

A reliable IBS diagnosis can be made by your gastroenterologist when:

  1. Ruling out alarm features or red flags:17
    • Onset of symptoms after age 50
    • Blood in the stool
    • Iron-deficiency anemia
    • Nocturnal (while sleeping) diarrhea
    • Weight loss
    • A family history of organic gastrointestinal disease: colorectal cancer, IBD, celiac disease

Patients with alarm features should be referred for further investigation before concluding they are suffering with IBS.

  1. The Rome IV Criteria for IBS are fulfilled for the last three months with symptom onset at least six months prior to diagnosis. You will have abdominal pain at least one day per week, along with at least two of the following18:
    • Related to defecation
    • Onset associated with a change in the frequency of stool
    • Onset associated with a change in the form (appearance) of stool
What are the causes of IBS?

While genetic predisposition can increase the likelihood that IBS will occur, additional inciting factors need to be present to develop IBS:

  • Childhood digestive troubles
  • History of previous physical, emotional, or sexual abuse
  • Parental modeling
  • Stress
  • Poor coping skills
  • Anxiety
  • Somatization
  • Depression
  • Infectious illnesses

IBS does not have a single cause and is considered a disorder of disturbed gut-brain interactions with different mechanisms involved:

  • Food sensitivities
  • Altered gut microbiota and metabolites
  • Increased intestinal permeability
  • Immune activation 
  • Visceral hypersensitivity (increased sensitivity of the internal organs to normal bodily sensations)
  • Psychological factors (stress, anxiety, and depression)
  • Abnormal gastrointestinal motility

Figure 3. Potential causes involved in the onset and development of IBS19.

A new theory suggests that a localized food allergy in the gut causes IBS pain. It turns out that a gut infection or stress can activate immune cells in the gut that mistakenly perceive food protein fragments (antigens) as enemies. After the  infection or stress disappears, the ingestion of food antigens again could explain the pain and cramping that often accompany a meal.20 

IBS isn't a single disease; it's a collection of distinct conditions for which we currently lack a definitive diagnostic test to categorize patients into true disease groups.

It’s important to discuss with the gastroenterologist if it makes sense to check for the following organic diseases, in case they are the root cause of the symptoms:21

  • Colorectal cancer
  • IBD (Crohn’s disease, ulcerative colitis, and microscopic colitis)
  • Gastrointestinal parasitic infections
  • Small intestinal bacterial overgrowth
  • Celiac disease
  • Bile acid diarrhea
  • Sucrase-isomaltase deficiency
  • Exocrine pancreatic insufficiency
  • Dyssynergic defecation

Since IBS can mimic many other medical issues, it is imperative that you do not self-diagnose with IBS and ask your physician to make a reliable diagnosis based on your symptoms and previous history.

Key components of integrated care for patients with IBS

Most diets for IBS rely on restricting well-known IBS triggers and only target gut symptoms. However, poor mental health is common in IBS and a higher psychological burden is associated with more visits to the gastroenterologist, more use of drugs for IBS, lower quality of life, and greater GI-specific anxiety.9

The management of IBS is not one-size-fits-all and involves multiple healthcare professionals and factors:10

  • Dietary therapies, including supplements, foods and drinks, and whole diets
  • Medical management
  • Behavioral management (e.g., gut-directed hypnotherapy)

Figure 1. The management of IBS is integrative and involves multiple evidence-based IBS treatments.10

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References

  1. Oka P, Parr H, Barberio B, et al. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020; 5(10):908-917. doi: 10.1016/S2468-1253(20)30217-X.
  2. Lacy BE, Mearin F, Chang L, et al. Bowel disorders. Gastroenterology. 2016; 150(6):1393-1407. doi: 10.1053/j.gastro.2016.02.031.
  3. Chey WD, Hashash JG, Manning L, et al. AGA clinical practice update on the role of diet in irritable bowel syndrome: expert review. Gastroenterology. 2022; 162(6):1737-1745.e5. doi: 10.1053/j.gastro.2021.12.248.
  4. Satherley R, Howard R, Higgs S. Disordered eating practices in gastrointestinal disorders. Appetite. 2015; 84:240-50. doi: 10.1016/j.appet.2014.10.006.
  5. Scarlata K, Zickgraf HF, Satherley RM, et al. A call to action: unraveling the nuance of adapted eating behaviors in individuals with gastrointestinal conditions. Clin Gastroenterol Hepatol. 2025; 23(6):893-901.e2. doi: 10.1016/j.cgh.2024.11.010.
  6. Melchior C, Algera J, Colomier E, et al. Food avoidance and restriction in irritable bowel syndrome: relevance for symptoms, quality of life and nutrient intake. Clin Gastroenterol Hepatol. 2022; 20(6):1290-1298.e4. doi: 10.1016/j.cgh.2021.07.004.
  7. Sato Y, Fukudo S. Gastrointestinal symptoms and disorders in patients with eating disorders. Clin J Gastroenterol. 2015; 8(5):255-63. doi: 10.1007/s12328-015-0611-x.
  8. Biesiekierski JR, Jonkers D, Ciacci C, et al. Non-coeliac gluten sensitivity. Lancet. 2025; 406(10518):2494-2508. doi: 10.1016/S0140-6736(25)01533-8.
  9. Black CJ, Ford AC. Global burden of irritable bowel syndrome: trends, predictions and risk factors. Nat Rev Gastroenterol Hepatol. 2020; 17(8):473-486. doi: 10.1038/s41575-020-0286-8.
  10. Chey WD, Keefer L, Whelan K, et al. Behavioral and diet therapies in integrated care for patients with irritable bowel syndrome. Gastroenterology. 2021; 160(1):47-62. doi: 10.1053/j.gastro.2020.06.099.
  11. Sturkenboom R, Keszthelyi D, Masclee AAM, et al. Discrete choice experiment reveals strong preference for dietary treatment among patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2022; 20(11):2628-2637. doi: 10.1016/j.cgh.2022.02.016.
  12. Gut Microbiota for Health. Diets for irritable bowel syndrome: what you need to know. Available on: https://www.gutmicrobiotaforhealth.com/diets-for-irritable-bowel-syndrome-what-you-need-to-know/
  13. Lacy BE, Mearin F, Chang L, et al. Bowel disorders. Gastroenterology. 2016; 150(6):1393-1407. doi: 10.1053/j.gastro.2016.02.031.
  14. Satherley R, Howard R, Higgs S. Disordered eating practices in gastrointestinal disorders. Appetite. 2015; 84:240-50. doi: 10.1016/j.appet.2014.10.006.
  15. Spiller R, Garsed K. Postinfectious irritable bowel syndrome. Gastroenterology. 2009; 136(6):1979-88. doi: 10.1053/j.gastro.2009.02.074.
  16. Almario CV, Yung Choi S, Chey WD, et al. Trends in prevalence of Rome IV disorders of gut-brain interaction during the COVID-19 pandemic: results from a nationally representative sample of over 160,000 people in the US. Neurogastroenterol Motil. 2025; e70020. doi: 10.1111/nmo.70020.
  17. Brandler J, Chey WD. Fishing for irritable bowel syndrome: which alarm features weave the best net? Clin Gastroenterol Hepatol. 2020; 20(2):276-278. doi: 10.1016/j.cgh.2020.11.020.
  18. Cash BD. Gastroenterology & Hepatology. 2020; 2018, 14(5 Suppl 3):3-15.
  19. Carco C, Young W, Gearry RB, et al. Increasing evidence that irritable bowel syndrome and functional gastrointestinal disorders have a microbial pathogenesis. Front Cell Infect Microbiol. 2020; 10:468. doi: 10.3389/fcimb.2020.00468.
  20. Ford AC, Staudacher HM, Talley NJ. Postprandial symptoms in disorders of gut-brain interaction and their potential as a treatment target. Gut. 2024; 73(7):1199-1211. doi: 10.1136/gutjnl-2023-331833.
  21. Frissora CL, Schiller LR. Getting the BS out of irritable bowel syndrome with diarrhea (IBS-D): let’s make a diagnosis. Curr Gastroenterol Rep. 2024; 26(1):20-29. doi: 10.1007/s11894-023-00909-1.

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